Mission Lucidity - decoding brain disease

Research

Extraordinary challenges require extraordinary efforts. Our research portfolio addresses the major obstacles of neurodegeneration research across multiple biological scales and disease stages.

Brain on a chip

We want to transform existing research models for neurodegeneration by creating experimental brain models based on patients' cells on an electrical chip.

Personalized risk profiling

We aim to create a tool to measure people’s genetic risk for Alzheimer’s disease and link this to the different underlying pathological mechanisms.

The eye as window to the brain

We are developing an advanced eye camera to scan the retina, the most accessible part of our central nervous system, to detect signs of neurodegenerative diseases long before the first symptoms. Earlier diagnosis via the eye is sensitive and non-invasive, and will allow us to follow disease progression over time, provide better individualized patient care, and evaluate the success of new therapies in clinical studies.

Electrical stimulation to protect the brain

Brain stimulation is an interesting option for the treatment of neurodegenerative diseases. In this project, we are developing a new, minimally invasive method to specifically stimulate the deep brain regions that are affected in Alzheimer's disease. We hope that this can delay cognitive decline and significantly improve the patients' quality of life.

Microfluidic chip technologies for brain organoid models

By developing microfluidic chip-based scaffolds, we aim to create improved organoid models that can revolutionize Alzheimer’s disease research.